EBOO Therapy: A Wellness Option People Travel Across the Southeast For

What Is EBOO Therapy?

EBOO stands for Extracorporeal Blood Oxygenation and Ozonation. It sounds complex, but the concept is elegant: extract your blood, treat it with medical-grade ozone in a controlled environment, and return it to your body. Many people choose EBOO as part of a wellness and longevity routine. Some patients tell us they feel more energy afterward. Everyone responds differently. Your provider screens you first to make sure it’s a good fit.

Unlike IV medications or oral drugs, EBOO uses your own blood and medical-grade ozone, which is why so many people are curious about it. It’s aimed at supporting your body’s natural repair, and results vary.

The EBOO Process (30-45 minutes):

1. A small amount of blood (100-150 ml) is drawn from your arm into a specialized container.
2. The blood flows through an ozone generator, where medical-grade ozone is carefully introduced.
3. Researchers are exploring how ozone may interact with your red blood cells, oxygen release and immune signals.
4. The treated blood is then returned to your body, and researchers are still exploring what effects this may have.

Why people ask about it: your cells run on oxygen and ATP (cellular energy). Many people want to support how they feel as they age. Practitioners are exploring how the oxygen and ozone used in EBOO may affect energy and how your cells work, and research is still early.

The EBOO Advantage

Charleston Pain Relief Center’s EBOO Legacy

• 18+ years offering EBOO therapy
• 396+ Google reviews
• Hundreds of EBOO sessions guided by our team
• State-of-the-art equipment and protocols
• Experienced team trained in European methods
• Serving patients from across the Southeast

Why CPRC is Your Regional Authority

• Only established EBOO provider in Southeast
• Comprehensive patient outcomes tracking
• Personalized plans for each person
• Integrates EBOO with stem cell, PRP therapies
• Easy access for regional patients
• Travel-friendly location for Southeast cities

What Our Patients Say

Patients from across the Southeast make the trip — read their reviews on Google.

Individual experiences vary.

Many patients pair their EBOO day with a weekend in Charleston.

Ask our team what your visit would look like.

Before Your Session

You’ll arrive 15 minutes early to our comfortable North Charleston clinic. Our team reviews your medical history, current symptoms, and treatment goals. We discuss what to expect and answer any questions. You’ll complete intake paperwork and meet with our EBOO specialist.

During Treatment

You’ll recline in a comfortable chair while a small amount of blood (100-150 ml) is drawn from your arm—about the same as a routine blood draw. The blood flows through our EBOO machine where medical-grade ozone is introduced. The ozone-treated blood is gently returned to your body. You may feel a mild tingling or warmth—this is common, and you can tell the team anytime.

After Your Session

You’re free to go immediately. No downtime. Most patients resume normal activities right away. Some report feeling energized within hours. Others notice changes over 48-72 hours, and everyone responds differently. We provide detailed aftercare instructions and schedule your next appointment if you’re doing a series.

The CPRC Advantage: Combine Therapies for Maximum Impact

At Charleston Pain Relief Center, we don’t view EBOO, stem cells, and PRP as competitors—we view them as complementary. Many people choose EBOO as part of a wellness and longevity routine. Stem cell therapy is aimed at supporting your body’s natural repair in a joint, and results vary. PRP uses concentrated growth factors aimed at supporting your body’s natural repair. Many patients benefit from combining protocols. For example, someone with long COVID who also has knee arthritis might choose EBOO as part of a wellness routine, plus stem cell therapy for their knee. Your provider will talk through whether combining them fits your plan. This integration is unique to CPRC and reflects our philosophy: regenerative medicine should address the whole person, not just one symptom.

Savannah, GA

Distance: 2 hours

Zero EBOO clinics in Savannah. You’re either driving to CPRC or flying to Europe. Choose Charleston.

Charlotte, NC

Distance: 3.5 hours

One or two clinics in Charlotte offer basic ozone IV. CPRC offers world-class EBOO. The drive is worth it.

Greenville, SC

Distance: 3 hours

Virtually no EBOO availability. CPRC is your closest access to elite regenerative medicine.

Hilton Head / Beaufort, SC

Distance: 1.5 hours

Closest major market to CPRC. Many locals choose EBOO as regular wellness optimization.

Myrtle Beach, SC

Distance: 1.5 hours

Growing patient base from Myrtle Beach. Easy drive. Many combine EBOO with weekend trips.

Fayetteville, NC

Distance: 3.5 hours

No established EBOO in Fayetteville. CPRC is your option for serious regenerative medicine.

Columbia, SC

Distance: 2.5 hours

CPRC is your regional hub. Most Columbia patients consider the 2.5-hour drive well worth it.

What is EBOO therapy?

EBOO stands for Extracorporeal Blood Oxygenation and Ozonation. It’s an advanced wellness therapy where a small amount of your blood is drawn, exposed to medical-grade ozone in a controlled external environment, and then returned to your body. The process takes about 30-45 minutes, and researchers are exploring how it may affect immune signals, oxygen use, inflammation and cellular energy (ATP). Think of it as a comprehensive biological tune-up. Your blood circulates through your entire body, which is why EBOO works with a small amount of your own blood. The ozone doesn’t stay in your blood, and researchers are still studying how it may affect your immune response after a session. This is different from taking a drug that leaves your body within hours. Some patients tell us they feel the effects for days afterward; everyone responds differently. The process is completely natural—your own blood is the treatment vehicle. Some European clinics have used EBOO for decades, and research is still early. At Charleston Pain Relief Center, our team has guided hundreds of people through their EBOO sessions.

Is EBOO provider-supervised?

This is a nuanced question that requires clarity. EBOO therapy is not FDA-approved to treat any condition. It is offered as a wellness service under your provider’s care. Medical procedures (like acupuncture, chiropractic, IV therapy, hyperbaric oxygen) operate under different regulatory frameworks than pharmaceuticals. The equipment used for EBOO is not FDA-approved to treat any specific condition, and research on EBOO is still early. EBOO has been used in parts of Europe for decades, and research is still early. Your provider can walk you through what is and isn’t known. The treatments are offered by licensed physicians in regulated clinical settings. At Charleston Pain Relief Center, all EBOO procedures are performed by experienced, credentialed medical professionals under strict safety protocols. Because EBOO is not regulated like a drug, your provider screens you first (labs, health history) to make sure it’s a good fit. Many wellness services are offered outside the drug approval pathway, which is why careful screening matters. If you have concerns about safety, we’re transparent about protocols, equipment, and outcomes. We encourage all patients to research EBOO independently and ask questions.

How many EBOO sessions do I need?

This varies depending on your condition, severity, and how your body responds. Most patients start with an initial series of 4-8 sessions spaced 2-4 weeks apart. This initial phase typically lasts 8-12 weeks and lets you and your provider see how you feel. Some conditions require fewer sessions—for example, someone doing EBOO for wellness optimization might do 4 sessions over 2 months. Others with longer-term wellness goals might do 8-12 sessions or monthly visits, based on their provider’s plan. At your consultation, we’ll assess your specific situation and recommend a personalized protocol. During your treatment series, we monitor your response through symptom tracking, energy levels, and, when relevant, lab markers. Some patients tell us they feel more energy after 2-3 sessions. Others notice changes after 4-6 sessions; everyone responds differently. After your initial series, some patients continue with monthly or quarterly “tune-up” sessions for ongoing optimization. Others complete their series and maintain benefits through lifestyle changes. The key point: EBOO isn’t a one-time fix. Most people do a series of sessions as part of an ongoing wellness routine. We customize every protocol to your goals and response.

What does EBOO feel like during treatment?

The physical sensation is minimal and comfortable. You’ll recline in a comfortable chair—similar to getting a blood draw or IV therapy. A trained technician will insert a small needle (similar to an IV) into your arm, which takes seconds and is minimally uncomfortable. The blood draws out slowly and steadily into the EBOO machine. You won’t feel the actual ozone treatment since your blood is being processed externally. The treated blood is then returned to your body through the same IV line. Most patients report feeling relaxed during treatment. Some bring music, meditation, or audiobooks to make the time even more pleasant. Many feel energized immediately after treatment, while others report effects develop over the next 24-48 hours. Everyone responds differently. A few patients report mild, temporary effects like tiredness, a headache or a mild flu-like feeling in the 24 hours after treatment. Let your provider know if this happens so they can adjust your plan. These effects resolve quickly. At CPRC, our comfortable environment and experienced technicians prioritize patient relaxation. You’ll never feel rushed or uncomfortable. Many patients describe EBOO sessions as genuinely pleasant—a chance to rest while your body receives cutting-edge medicine.

Can EBOO help with neuropathy?

People living with neuropathy often ask us about EBOO; it is not FDA-approved to treat neuropathy, and research is still early. Neuropathy occurs when nerve tissue is damaged, resulting in pain, numbness, tingling, and burning sensations—often in feet and hands. The underlying problem is usually poor blood circulation, nerve inflammation, and mitochondrial dysfunction (low cellular energy in nerve cells). Traditional medicine offers limited solutions. Pain medications mask symptoms without addressing causes. Gabapentin and pregabalin have significant side effects. Many neuropathy patients are told to simply accept their condition. Many people with neuropathy want options alongside their current care. Researchers are exploring how ozone may affect circulation and inflammation, and your provider will talk through whether EBOO may fit your overall plan for nerve pain relief. Some patients tell us they feel more comfortable after a series. Everyone responds differently. The timeframe varies—some patients feel improvement after 1-2 sessions, while others notice gradual improvement over 4-6 weeks. We recommend combining EBOO with lifestyle modifications: better glucose control (if diabetic), nerve-supporting supplements (alpha-lipoic acid, B vitamins), and physical activity. Your provider will help you build a plan that fits. If you have neuropathy and want to explore options alongside your current care, EBOO may be worth a conversation with your provider.

Is EBOO safe?

Like any procedure, EBOO carries some risks, so it is done by trained staff using proper equipment after your provider screens you first. EBOO has been used in European clinics for decades, and research is still early. Safety concerns often stem from confusion about ozone. Ozone gas itself is toxic if inhaled directly into lungs—this is true. However, EBOO therapy uses medical-grade ozone in a controlled, closed system where your blood is the only medium exposed. Researchers are still studying how ozone interacts with your blood during treatment. Your lungs are never exposed. Your provider sets the ozone dose carefully. Serious side effects are uncommon, but they can happen, which is why screening matters. The most common minor side effects (which occur in 5-10% of patients) are temporary and mild: headache, fatigue, or mild flu-like symptoms within 24 hours of treatment. Tell your provider about any symptoms so they can adjust your plan. These usually pass within a day. Some people should not have EBOO. People with severe G6PD deficiency (a rare genetic condition) cannot have EBOO. If you are pregnant, you should avoid EBOO as a precaution. Patients on blood thinners require special monitoring but can still receive EBOO. At CPRC, we conduct thorough health screening before EBOO to ensure you’re a good candidate. Our equipment is state-of-the-art and regularly maintained. Our technicians are extensively trained. We follow European safety protocols refined over three decades. If you’re concerned about safety, we’re happy to discuss your specific medical situation and answer detailed questions. Transparency and safety are our highest priorities.

Does insurance cover EBOO?

Unfortunately, most insurance companies do not cover EBOO therapy in the United States. Insurance companies classify EBOO as experimental because it is not FDA-approved for any condition and research is still early, even though it has been studied in other countries. Insurance coverage for regenerative medicine in general is limited. Stem cell therapy, PRP, and IV therapies are similarly rarely covered. The insurance industry moves slowly and typically only covers treatments with extensive U.S.-based published research and widespread adoption. EBOO has both internationally, but not yet in America. This is likely to change as EBOO gains awareness and more U.S. clinics offer it. That said, EBOO costs are significantly lower than many medical interventions. A typical initial EBOO series (4-8 sessions) costs $3,500-$6,000 total—roughly equivalent to one orthopedic surgery consultation or a few months of prescription medications. When you compare EBOO to the cost of managing chronic disease with pharmaceuticals over years, EBOO is extremely cost-effective. Many patients find it’s worth paying out-of-pocket. Some health savings accounts (HSAs) or flexible spending accounts (FSAs) may cover EBOO—check with your account administrator. We also offer payment plans to make EBOO accessible. At your consultation, we’ll discuss exact costs for your personalized protocol and explore all financial options.

How is EBOO different from ozone IV therapy?

This is an important distinction because many clinics market “ozone therapy” or “ozone IV,” which sounds similar to EBOO but works differently. Ozone IV therapy (sometimes called MAH—major autohemous therapy, or ozone infusion) involves drawing a small amount of blood, mixing it with ozone gas, and returning it directly to your body, usually by IV infusion. The ozone exposure is brief and less controlled. EBOO (extracorporeal blood oxygenation and ozonation) is more sophisticated. A larger volume of blood is drawn and circulated through a specialized chamber where ozone is precisely introduced and your blood is continuously oxygenated. The blood is thoroughly treated before being returned. Researchers are still exploring how these methods compare. Think of ozone IV as a basic ozone exposure. EBOO treats a larger volume with more dosing control. Some patients who tried ozone IV tell us they prefer EBOO. Everyone responds differently. Some clinics use the terms interchangeably, which creates confusion. At CPRC, we specifically offer EBOO—the more involved protocol. If you’ve tried ozone IV elsewhere, your provider can talk through how EBOO differs. The mechanisms are related but not equivalent. EBOO is what serious regenerative medicine clinics offer.

Can EBOO help with long COVID symptoms?

It’s a common question, and here’s what we can and can’t say. Long COVID represents a post-viral syndrome where patients experience persistent symptoms months or years after initial COVID-19 infection. Common long COVID symptoms include chronic fatigue, brain fog, shortness of breath, chest pain, heart palpitations, autoimmune flares, and neurological symptoms. Traditional medicine has limited solutions. Doctors often tell long COVID patients their symptoms are psychological or that they need to “just exercise.” However, emerging research shows long COVID involves persistent viral reservoirs, microclot formation, endothelial dysfunction, and chronic immune dysregulation. Researchers are exploring whether EBOO may relate to any of these, and research is still early. People living with long COVID often ask us about EBOO; it is not FDA-approved to treat long COVID, and research is still early. Many people living with long COVID have asked us about EBOO. Some tell us they feel more energy afterward. Everyone responds differently. Experiences vary widely from person to person. Your provider can explain how EBOO may fit with other services you’re considering. Long COVID is complex and individual responses vary, so treatment must be personalized. If you are living with long COVID and looking for options, your provider will talk through whether EBOO may fit your overall plan alongside the care you already get. Many patients tell us they’re glad they asked questions and explored their options.

What should I do to prepare for EBOO?

Preparation for EBOO is minimal, but a few things optimize results. First, hydration is critical. Drink plenty of water for 2-3 days before your session. Dehydration makes blood drawing more difficult and reduces treatment effectiveness. We recommend drinking half your body weight in ounces of water daily (a 200-pound person drinks 100 ounces). Second, avoid heavy meals immediately before treatment. A light breakfast or lunch is fine, but don’t arrive on an empty stomach—low blood sugar can make you feel faint. Third, avoid strenuous exercise 24 hours before treatment. Your body needs to be in a relaxed state. Fourth, avoid alcohol 24 hours before and 48 hours after treatment. Alcohol interferes with immune activation. Fifth, take any regular medications as prescribed unless instructed otherwise by our team. Sixth, bring a list of all supplements you’re taking—some may need adjustment. Seventh, wear loose, comfortable clothing that allows easy arm access for the IV. We’ll also discuss any concerning symptoms or medications at your pre-treatment consultation. After treatment, rest for the remainder of the day. Most people can return to normal activities the next day, but strenuous exercise should be avoided for 48 hours to allow your body to fully integrate the treatment. Light walking and stretching are beneficial. Stay well-hydrated post-treatment. If you notice a headache, tiredness or mild flu-like feelings, let your provider know right away so they can guide you. Drink more water and rest. If symptoms persist beyond 48 hours, contact our team. Overall, EBOO requires minimal lifestyle disruption—just basic preparation and recovery wisdom.

Is EBOO available near me in the Southeast?

Short answer: Probably not, which is why patients from across the Southeast travel to Charleston Pain Relief Center. EBOO therapy is extremely rare in the United States. We estimate fewer than 100 clinics nationwide offer true EBOO. The Southeast is particularly underserved—outside of CPRC, finding EBOO is nearly impossible. Some clinics in major cities (Atlanta, Charlotte, Miami) may offer basic ozone IV therapy, which is a different method from EBOO. A few clinics advertise “ozone therapy” but are actually offering low-grade variations that are not the same as EBOO. Charleston Pain Relief Center is the established authority on EBOO in the entire Southeast. Our team focuses on EBOO and guides people through it every week. If you search for EBOO in your city and find nothing, you’re in the majority. This is actually part of the reason patients travel to CPRC—there’s no competing provider. We’re the destination for serious regenerative medicine in the region. If you’re within a 4-hour drive of Charleston (which includes Savannah, Hilton Head, Myrtle Beach, Charlotte, Greenville, Columbia, and parts of North Carolina), CPRC is realistically your closest access to world-class EBOO. We make the travel convenient with flexible scheduling, comfortable facilities, and often patients combine treatment with a Charleston weekend. Many patients describe the drive as a small price to pay for access to care they can’t find closer to home.

How soon will I feel results from EBOO?

Timeline varies significantly depending on your condition and individual biology, but here’s what to expect: Some patients feel noticeable changes within hours. Some say they feel more energy, clearer thinking or a better mood, and everyone responds differently. Others don’t notice anything immediately but report feeling significantly better 48-72 hours after treatment. Researchers are still exploring why responses differ. For longer-term wellness goals, any changes people notice tend to come gradually over 2-4 weeks. You might notice gradual pain reduction, improved energy, or better sleep. By 4-6 sessions (8-12 weeks), many people have a clearer sense of how they respond. Some conditions take longer. People living with Lyme often ask us about EBOO; it is not FDA-approved to treat Lyme, and research is still early. This reflects the complexity of the condition. People with long COVID who ask about EBOO report a wide range of experiences. The key principle: EBOO works cumulatively. Most people do a series, and your provider checks in after each session. Many people have a better sense of how they feel after a few sessions than after one. This is why we recommend 4-8 session series rather than one-off treatments. Patience is rewarded. If you don’t feel improvement after 4 sessions, we reassess and may adjust your protocol or recommend additional diagnostics. Many people have a sense of how they respond by session 3-4. The bottom line: everyone responds differently, so plan for a 4-8 week series and check in with your provider. Once you achieve your goals, many patients maintain benefits with quarterly “tune-up” sessions or lifestyle optimization.

Can I combine EBOO with stem cell therapy?

Yes, many people ask about this, based on their provider’s plan. Many CPRC patients benefit from combining EBOO with stem cell therapy or PRP. Here’s why the combination works: Stem cell therapy is local—it is aimed at supporting your body’s own repair in joints, cartilage, or tissues. EBOO is a whole-body wellness session. Researchers are still exploring how the two may work together. Results vary. Some patients choose stem cell therapy for knee arthritis plus EBOO as part of a wellness routine, and everyone responds differently. The stem cells support repair in their joint, while EBOO is part of their overall wellness routine. Another example: someone with long COVID who also has neuropathy might ask about EBOO as part of a wellness routine plus stem cell therapy, and your provider will talk through what fits. The protocols complement each other. Timing matters. Some patients start with EBOO and add stem cell therapy later, and your provider will talk through the order that fits your plan. Alternatively, some patients do stem cell therapy first, then add EBOO as part of their wellness routine. We customize the sequence based on your specific situation. Combining therapies increases overall cost, so your provider will talk through what fits your budget and goals. You’re building one plan instead of several separate ones. At CPRC, we excel at integrating different regenerative protocols into cohesive treatment plans. This integrated approach is unique to forward-thinking clinics. If you’re considering multiple regenerative therapies, our team will design a plan that makes them work together optimally.

Who should NOT get EBOO?

EBOO is not a fit for everyone, and a few groups should avoid it. Understanding contraindications helps ensure you’re protected. First, anyone with severe G6PD deficiency (a genetic condition affecting red blood cells) cannot have EBOO. The ozone exposure could trigger hemolysis (red blood cell breakdown). If you know you have G6PD deficiency, inform us immediately. G6PD testing is simple if you’re unsure. Second, if you are pregnant, you should avoid EBOO as a precaution. We recommend waiting until after pregnancy and nursing to avoid any theoretical risk. Third, patients with active tuberculosis or certain infections may need to avoid EBOO during acute infection—antibodies are being generated and EBOO might interfere with that process. Discuss with our team if you have active infection. Fourth, people with severe uncontrolled heart arrhythmias or unstable cardiovascular conditions should be evaluated carefully. Your provider checks your heart health first to make sure EBOO is a good fit for you. Fifth, patients with severe clotting disorders (beyond those managed by blood thinners) may not be good candidates. Our screening process identifies these. Sixth, anyone with an allergy or sensitivity to ozone (extremely rare) cannot have EBOO. Seventh, patients actively undergoing chemotherapy should check with their oncologist first—sometimes EBOO can enhance chemo effects, sometimes it should be spaced out. Beyond these groups, your provider screens you first (labs, health history) to make sure it’s a good fit. We screen all new patients thoroughly to ensure safety. If you have any medical condition you’re uncertain about, mention it at your consultation. Our job is to determine if EBOO is right for you.

Why travel to CPRC for EBOO instead of a local clinic?

This gets to the heart of why patients from across the Southeast choose Charleston Pain Relief Center. If you have a local EBOO clinic available, you might wonder: why travel? Several reasons make CPRC worth the drive. First, experience and reputation. We’ve been offering EBOO for 18+ years—longer than nearly any U.S. clinic. Our team has treated hundreds of patients and refined protocols based on real outcomes. You’re not an experiment. You’re benefiting from nearly two decades of accumulated wisdom. Second, equipment and protocols. We use state-of-the-art German-designed EBOO equipment maintained to the highest standards. Our protocols are based on European standards (the gold standard globally) not American shortcuts. Third, expertise. Our physicians and technicians are specifically trained in regenerative medicine, not just administering basic EBOO. We understand how to combine EBOO with stem cell therapy, PRP, and other protocols. We can personalize treatment based on your specific condition. Fourth, track record. Our 396+ Google reviews aren’t random—they reflect consistent, exceptional outcomes. Patients travel to CPRC because they’ve heard from others that we deliver results. Fifth, integration. We can coordinate EBOO with other regenerative therapies at CPRC. If you need both EBOO and stem cells, you’re getting a coordinated, synergistic plan—not two unrelated treatments. Sixth, patient experience. We’ve invested in creating a comfortable, professional, welcoming environment. You’re not in a rush. Our staff takes time with you. Finally, if a local clinic offers something called “EBOO” but you’ve never heard of it or found limited information about it online, be cautious. CPRC’s reputation is established and verifiable. We’re a known entity. For serious regenerative medicine, that matters. Bottom line: proximity is convenient, but experience matters too. Many patients who initially seek local options eventually choose CPRC after research. Many patients feel the drive is worth it to work with a team that focuses on these therapies every day.