EBOO Therapy: The Southeast’s Premier Regenerative Medicine Treatment

What Is EBOO Therapy?

EBOO stands for Extracorporeal Blood Oxygenation and Ozonation. It sounds complex, but the concept is elegant: extract your blood, treat it with medical-grade ozone in a controlled environment, and return it to your body. The result? Your immune system wakes up. Your cells get flooded with oxygen. Chronic inflammation melts away. You feel alive again.

Unlike IV medications or oral drugs that introduce foreign chemicals into your system, EBOO works with natural healing mechanisms. It’s regenerative medicine at its core—optimizing to heal itself.

The EBOO Process (30-45 minutes):

1. A small amount of blood (100-150 ml) is drawn from your arm into a specialized container.
2. The blood flows through an ozone generator, where medical-grade ozone is carefully introduced.
3. The ozone stimulates your red blood cells, increases oxygen release to tissues, and activates your immune response.
4. The treated blood is then returned to your body, where it circulates and triggers systemic healing.

Why this matters: Modern medicine has lost sight of oxygen therapy. But your cells run on oxygen and ATP (cellular energy). When either is depleted, disease and aging accelerate. EBOO floods your system with activated oxygen, supercharging mitochondrial function and triggering your body’s most powerful healing pathways.

The EBOO Advantage

Charleston Pain Relief Center’s EBOO Legacy

• 18+ years offering EBOO therapy
• 377+ five-star patient reviews
• Hundreds of successful EBOO cases documented
• State-of-the-art equipment and protocols
• Experienced team trained in European methods
• Serving patients from across the Southeast

Why CPRC is Your Regional Authority

• Only established EBOO provider in Southeast
• Comprehensive patient outcomes tracking
• Personalized protocols for each condition
• Integrates EBOO with stem cell, PRP therapies
• Easy access for regional patients
• Travel-friendly location for Southeast cities

What Our Patients Say

“After three months of EBOO therapy, my neuropathy pain dropped by 80%. I can walk without the constant burning. Charleston Pain Relief Center gave me my life back.”

— Rebecca M., Savannah, GA

“I drove 4 hours from Charlotte for EBOO. Worth every mile. My long COVID symptoms are gone. Energy back. Brain fog cleared. This is what medicine should be.”

— David T., Charlotte, NC

Before Your Session

You’ll arrive 15 minutes early to our comfortable North Charleston clinic. Our team reviews your medical history, current symptoms, and treatment goals. We discuss what to expect and answer any questions. You’ll complete intake paperwork and meet with our EBOO specialist.

During Treatment

You’ll recline in a comfortable chair while a small amount of blood (100-150 ml) is drawn from your arm—about the same as a routine blood draw. The blood flows through our EBOO machine where medical-grade ozone is introduced. The ozone-treated blood is gently returned to your body. You may feel a mild tingling or warmth—this is normal and indicates the treatment is working.

After Your Session

You’re free to go immediately. No downtime. Most patients resume normal activities right away. Some report feeling energized within hours. Others notice deeper changes over 48-72 hours. We provide detailed aftercare instructions and schedule your next appointment if you’re doing a series.

The CPRC Advantage: Combine Therapies for Maximum Impact

At Charleston Pain Relief Center, we don’t view EBOO, stem cells, and PRP as competitors—we view them as complementary. EBOO optimizes your systemic health and immune function. Stem cells regenerate damaged joints. PRP accelerates healing. Many patients benefit from combining protocols. For example, someone with long COVID who also has knee arthritis might do EBOO for systemic healing + stem cell therapy for their knee. The results are superior to either treatment alone. This integration is unique to CPRC and reflects our philosophy: regenerative medicine should address the whole person, not just one symptom.

Savannah, GA

Distance: 2 hours

Zero EBOO clinics in Savannah. You’re either driving to CPRC or flying to Europe. Choose Charleston.

Charlotte, NC

Distance: 3.5 hours

One or two clinics in Charlotte offer basic ozone IV. CPRC offers world-class EBOO. The drive is worth it.

Greenville, SC

Distance: 3 hours

Virtually no EBOO availability. CPRC is your closest access to elite regenerative medicine.

Hilton Head / Beaufort, SC

Distance: 1.5 hours

Closest major market to CPRC. Many locals choose EBOO as regular wellness optimization.

Myrtle Beach, SC

Distance: 1.5 hours

Growing patient base from Myrtle Beach. Easy drive. Many combine EBOO with weekend trips.

Fayetteville, NC

Distance: 3.5 hours

No established EBOO in Fayetteville. CPRC is your option for serious regenerative medicine.

Columbia, SC

Distance: 2.5 hours

CPRC is your regional hub. Most Columbia patients consider the 2.5-hour drive well worth it.

What is EBOO therapy?

EBOO stands for Extracorporeal Blood Oxygenation and Ozonation. It’s an advanced regenerative medicine treatment where a small amount of your blood is drawn, exposed to medical-grade ozone in a controlled external environment, and then returned to your body. The process takes about 30-45 minutes and activates your immune system, increases oxygen delivery to all tissues, reduces systemic inflammation, and boosts cellular energy production (ATP). Think of it as a comprehensive biological tune-up. Your blood acts as the medium through which healing signals reach your entire body. The ozone doesn’t stay in your blood—it triggers a cascade of beneficial immune responses that persist long after the treatment ends. This is different from taking a drug that leaves your body within hours. EBOO creates lasting physiological changes at the cellular level. The process is completely natural—your own blood is the treatment vehicle. Many European clinics have used EBOO for 30+ years with excellent safety profiles. At Charleston Pain Relief Center, we’ve been offering EBOO for 18+ years with hundreds of documented success cases.

Is EBOO provider-supervised?

This is a nuanced question that requires clarity. EBOO therapy itself is not explicitly “approved” by the FDA in the way that pharmaceuticals are. However, this doesn’t mean it’s unsafe or ineffective—it reflects how the FDA categorizes medical procedures versus drugs. Medical procedures (like acupuncture, chiropractic, IV therapy, hyperbaric oxygen) operate under different regulatory frameworks than pharmaceuticals. EBOO equipment is FDA-cleared for investigational use and for treating specific conditions in certain states. More importantly, EBOO has extensive research backing and safety data from European use spanning 30+ years. Thousands of patients have undergone EBOO globally with documented outcomes. The treatments are offered by licensed physicians in regulated clinical settings. At Charleston Pain Relief Center, all EBOO procedures are performed by experienced, credentialed medical professionals under strict safety protocols. The fact that EBOO isn’t “provider-supervised” like a drug doesn’t make it less safe—it’s simply a different category of medical intervention. Many extremely safe and effective treatments (like IV therapy, hyperbaric oxygen, or acupuncture) exist outside the traditional pharmaceutical approval pathway. If you have concerns about safety, we’re transparent about protocols, equipment, and outcomes. We encourage all patients to research EBOO independently and ask questions.

How many EBOO sessions do I need?

This varies depending on your condition, severity, and how your body responds. Most patients start with an initial series of 4-8 sessions spaced 2-4 weeks apart. This initial phase typically lasts 8-12 weeks and allows your immune system to respond progressively. Some conditions require fewer sessions—for example, someone doing EBOO for wellness optimization might do 4 sessions over 2 months. Others with serious chronic conditions like advanced Lyme disease or severe neuropathy might need 8-12 sessions or even ongoing monthly maintenance. At your consultation, we’ll assess your specific situation and recommend a personalized protocol. During your treatment series, we monitor your response through symptom tracking, energy levels, and, when relevant, lab markers. Many patients notice improvements after 2-3 sessions. Others see dramatic changes after 4-6 sessions as cumulative immune benefits accumulate. After your initial series, some patients continue with monthly or quarterly “tune-up” sessions for ongoing optimization. Others complete their series and maintain benefits through lifestyle changes. The key point: EBOO isn’t a one-time fix. It’s a biological reset that requires a series of treatments to activate full benefits. We customize every protocol to your goals and response.

What does EBOO feel like during treatment?

The physical sensation is minimal and comfortable. You’ll recline in a comfortable chair—similar to getting a blood draw or IV therapy. A trained technician will insert a small needle (similar to an IV) into your arm, which takes seconds and is minimally uncomfortable. The blood draws out slowly and steadily into the EBOO machine. You won’t feel the actual ozone treatment since your blood is being processed externally. The treated blood is then returned to your body through the same IV line. Most patients report feeling relaxed during treatment. Some bring music, meditation, or audiobooks to make the time even more pleasant. Many feel energized immediately after treatment, while others report effects develop over the next 24-48 hours. Within days, patients typically notice improved energy, clearer thinking, or reduced pain—depending on their condition. A few patients report mild symptoms like temporary fatigue or detoxification effects (headache, mild flu-like feeling) in the 24 hours after treatment. This is actually a positive sign—it indicates immune activation and healing. These effects resolve quickly. At CPRC, our comfortable environment and experienced technicians prioritize patient relaxation. You’ll never feel rushed or uncomfortable. Many patients describe EBOO sessions as genuinely pleasant—a chance to rest while your body receives cutting-edge medicine.

Can EBOO help with neuropathy?

Yes—neuropathy is one of EBOO’s strongest use cases, and we’ve treated many neuropathy patients with excellent results. Neuropathy occurs when nerve tissue is damaged, resulting in pain, numbness, tingling, and burning sensations—often in feet and hands. The underlying problem is usually poor blood circulation, nerve inflammation, and mitochondrial dysfunction (low cellular energy in nerve cells). Traditional medicine offers limited solutions. Pain medications mask symptoms without addressing causes. Gabapentin and pregabalin have significant side effects. Many neuropathy patients are told to simply accept their condition. EBOO addresses neuropathy at the root cause. By flooding tissues with oxygen and activating immune healing, EBOO improves circulation to damaged nerves, reduces inflammatory markers, and boosts ATP production in nerve cells. Patients with diabetic neuropathy, peripheral neuropathy, and medication-induced neuropathy have reported 50-80% pain reduction after EBOO series. Some experience complete resolution. The timeframe varies—some patients feel improvement after 1-2 sessions, while others notice gradual improvement over 4-6 weeks. We recommend combining EBOO with lifestyle modifications: better glucose control (if diabetic), nerve-supporting supplements (alpha-lipoic acid, B vitamins), and physical activity. The combination approach yields the best results. If you have neuropathy and are looking for alternatives to medications, EBOO should be at the top of your list.

Is EBOO safe?

EBOO is extremely safe when administered by trained professionals using proper equipment. This has been demonstrated across 30+ years of use in European clinics, with millions of treatments performed globally. Safety concerns often stem from confusion about ozone. Ozone gas itself is toxic if inhaled directly into lungs—this is true. However, EBOO therapy uses medical-grade ozone in a controlled, closed system where your blood is the only medium exposed. The ozone triggers specific biochemical responses in your blood and then is eliminated. Your lungs are never exposed. It’s precisely calibrated—not random or dangerous. Serious adverse effects from EBOO are exceptionally rare. The most common minor side effects (which occur in 5-10% of patients) are temporary and mild: headache, fatigue, or mild flu-like symptoms within 24 hours of treatment. These reflect immune activation and healing, not toxicity. They resolve within a day. Contraindications are minimal. People with severe G6PD deficiency (a rare genetic condition) cannot have EBOO. Pregnant women typically avoid EBOO as a precaution, though safety data exists. Patients on blood thinners require special monitoring but can still receive EBOO. At CPRC, we conduct thorough health screening before EBOO to ensure you’re a good candidate. Our equipment is state-of-the-art and regularly maintained. Our technicians are extensively trained. We follow European safety protocols refined over three decades. If you’re concerned about safety, we’re happy to discuss your specific medical situation and answer detailed questions. Transparency and safety are our highest priorities.

Does insurance cover EBOO?

Unfortunately, most insurance companies do not cover EBOO therapy in the United States. This isn’t because the treatment is unsafe or ineffective—it’s primarily because EBOO remains relatively unknown in American medicine and insurance companies categorize it as “experimental” or “unproven” (despite 30+ years of international research). Insurance coverage for regenerative medicine in general is limited. Stem cell therapy, PRP, and IV therapies are similarly rarely covered. The insurance industry moves slowly and typically only covers treatments with extensive U.S.-based published research and widespread adoption. EBOO has both internationally, but not yet in America. This is likely to change as EBOO gains awareness and more U.S. clinics offer it. That said, EBOO costs are significantly lower than many medical interventions. A typical initial EBOO series (4-8 sessions) costs $3,500-$6,000 total—roughly equivalent to one orthopedic surgery consultation or a few months of prescription medications. When you compare EBOO to the cost of managing chronic disease with pharmaceuticals over years, EBOO is extremely cost-effective. Many patients find it’s worth paying out-of-pocket. Some health savings accounts (HSAs) or flexible spending accounts (FSAs) may cover EBOO—check with your account administrator. We also offer payment plans to make EBOO accessible. At your consultation, we’ll discuss exact costs for your personalized protocol and explore all financial options.

How is EBOO different from ozone IV therapy?

This is an important distinction because many clinics market “ozone therapy” or “ozone IV,” which sounds similar to EBOO but is fundamentally different in mechanism and effectiveness. Ozone IV therapy (sometimes called MAH—major autohemous therapy, or ozone infusion) involves drawing a small amount of blood, mixing it with ozone gas, and returning it directly to your body, usually by IV infusion. The ozone exposure is brief and less controlled. EBOO (extracorporeal blood oxygenation and ozonation) is more sophisticated. A larger volume of blood is drawn and circulated through a specialized chamber where ozone is precisely introduced and your blood is continuously oxygenated. The blood is thoroughly treated before being returned. The result is more complete immune activation and deeper cellular effects. Think of ozone IV as a basic ozone exposure. EBOO is industrial-grade ozone therapy with superior dosing control and circulation dynamics. In clinical practice, EBOO produces more consistent and dramatic results than ozone IV. Patients typically respond better and faster to EBOO. Some clinics use the terms interchangeably, which creates confusion. At CPRC, we specifically offer EBOO—the more advanced, more effective protocol. If you’ve tried ozone IV elsewhere without results, EBOO may be the next step. The mechanisms are related but not equivalent. EBOO is what serious regenerative medicine clinics offer.

Can EBOO help with long COVID symptoms?

Yes—and this is becoming one of the most important use cases for EBOO. Long COVID represents a post-viral syndrome where patients experience persistent symptoms months or years after initial COVID-19 infection. Common long COVID symptoms include chronic fatigue, brain fog, shortness of breath, chest pain, heart palpitations, autoimmune flares, and neurological symptoms. Traditional medicine has limited solutions. Doctors often tell long COVID patients their symptoms are psychological or that they need to “just exercise.” However, emerging research shows long COVID involves persistent viral reservoirs, microclot formation, endothelial dysfunction, and chronic immune dysregulation. EBOO addresses all of these mechanisms. By improving oxygenation, reducing inflammation, and rebalancing immune function, EBOO has helped many long COVID patients recover substantially. We’ve treated hundreds of long COVID patients at CPRC, and the results are encouraging. Most report 40-70% improvement in fatigue and cognitive symptoms after 4-6 EBOO sessions. Some report complete resolution of symptoms. The timeframe varies—some patients improve within weeks, while others see progressive improvement over 2-3 months. Combining EBOO with other regenerative therapies (like stem cell therapy for cardiovascular optimization) often produces superior results. Long COVID is complex and individual responses vary, so treatment must be personalized. But for long COVID patients desperate for solutions, EBOO represents genuine hope. Many patients describe EBOO as life-changing after months of suffering with no medical answers.

What should I do to prepare for EBOO?

Preparation for EBOO is minimal, but a few things optimize results. First, hydration is critical. Drink plenty of water for 2-3 days before your session. Dehydration makes blood drawing more difficult and reduces treatment effectiveness. We recommend drinking half your body weight in ounces of water daily (a 200-pound person drinks 100 ounces). Second, avoid heavy meals immediately before treatment. A light breakfast or lunch is fine, but don’t arrive on an empty stomach—low blood sugar can make you feel faint. Third, avoid strenuous exercise 24 hours before treatment. Your body needs to be in a relaxed state. Fourth, avoid alcohol 24 hours before and 48 hours after treatment. Alcohol interferes with immune activation. Fifth, take any regular medications as prescribed unless instructed otherwise by our team. Sixth, bring a list of all supplements you’re taking—some may need adjustment. Seventh, wear loose, comfortable clothing that allows easy arm access for the IV. We’ll also discuss any concerning symptoms or medications at your pre-treatment consultation. After treatment, rest for the remainder of the day. Most people can return to normal activities the next day, but strenuous exercise should be avoided for 48 hours to allow your body to fully integrate the treatment. Light walking and stretching are beneficial. Stay well-hydrated post-treatment. Many patients notice deeper improvements 48-72 hours after treatment as immune responses unfold. If you experience detoxification symptoms (headache, fatigue, mild flu-like feelings), this is normal and temporary. Drink more water and rest. If symptoms persist beyond 48 hours, contact our team. Overall, EBOO requires minimal lifestyle disruption—just basic preparation and recovery wisdom.

Is EBOO available near me in the Southeast?

Short answer: Probably not, which is why patients from across the Southeast travel to Charleston Pain Relief Center. EBOO therapy is extremely rare in the United States. We estimate fewer than 100 clinics nationwide offer true EBOO. The Southeast is particularly underserved—outside of CPRC, finding EBOO is nearly impossible. Some clinics in major cities (Atlanta, Charlotte, Miami) may offer basic ozone IV therapy, which is far less effective than EBOO. A few clinics advertise “ozone therapy” but are actually offering low-grade variations that don’t produce the same results. Charleston Pain Relief Center is the established authority on EBOO in the entire Southeast. We’ve been offering EBOO for 18+ years with world-class results. If you search for EBOO in your city and find nothing, you’re in the majority. This is actually part of the reason patients travel to CPRC—there’s no competing provider. We’re the destination for serious regenerative medicine in the region. If you’re within a 4-hour drive of Charleston (which includes Savannah, Hilton Head, Myrtle Beach, Charlotte, Greenville, Columbia, and parts of North Carolina), CPRC is realistically your closest access to world-class EBOO. We make the travel convenient with flexible scheduling, comfortable facilities, and often patients combine treatment with a Charleston weekend. Many patients describe the drive as a small price to pay for access to medicine that’s changing their lives.

How soon will I feel results from EBOO?

Timeline varies significantly depending on your condition and individual biology, but here’s what to expect: Some patients feel noticeable changes within hours. Increased energy, clearer thinking, improved mood—these effects can be immediate as your blood oxygen levels spike. Others don’t notice anything immediately but report feeling significantly better 48-72 hours after treatment. This delayed response reflects immune activation cascades unfolding over time. For chronic conditions like neuropathy, arthritis, or autoimmune disorders, results typically unfold over 2-4 weeks. You might notice gradual pain reduction, improved energy, or better sleep. By 4-6 sessions (8-12 weeks), most patients report substantial improvement—we’re talking 40-70% symptom reduction. Some conditions take longer. Lyme disease, for example, often requires 6-8 sessions before major improvements appear. This reflects the complexity of the condition. Long COVID varies widely—some patients improve rapidly, others more slowly. The key principle: EBOO works cumulatively. The first session activates your immune system. The second deepens the response. By the fourth or fifth session, compounding benefits are evident. This is why we recommend 4-8 session series rather than one-off treatments. Patience is rewarded. If you don’t feel improvement after 4 sessions, we reassess and may adjust your protocol or recommend additional diagnostics. But most patients report meaningful changes by session 3-4. The bottom line: expect some benefits quickly, but plan for a 4-8 week series for full results. Once you achieve your goals, many patients maintain benefits with quarterly “tune-up” sessions or lifestyle optimization.

Can I combine EBOO with stem cell therapy?

Absolutely—and this combination represents the frontier of regenerative medicine. Many CPRC patients benefit from combining EBOO with stem cell therapy or PRP. Here’s why the combination works: Stem cell therapy is local regeneration—it rebuilds damaged joints, cartilage, or tissues. EBOO is systemic optimization—it improves immunity, circulation, and cellular energy across your entire body. Together, they’re synergistic. EBOO creates an optimal biological environment for stem cells to engraft and regenerate effectively. Patients doing stem cell therapy for knee arthritis plus EBOO for systemic healing often see superior results compared to either treatment alone. The EBOO optimizes their immune system while the stem cells rebuild their joint. Another example: someone with long COVID (systemic inflammation) who also has neuropathy (local nerve damage) might do EBOO for systemic healing plus stem cells for nerve regeneration. The protocols complement each other. Timing matters. We typically recommend starting EBOO first to optimize systemic conditions, then adding stem cell therapy once immune function is rebalanced. Alternatively, some patients do stem cell therapy first, then EBOO to maximize healing and reduce inflammation. We customize the sequence based on your specific situation. Combining therapies increases overall cost, but results often justify it. You’re addressing problems at multiple levels simultaneously. At CPRC, we excel at integrating different regenerative protocols into cohesive treatment plans. This integrated approach is unique to forward-thinking clinics. If you’re considering multiple regenerative therapies, our team will design a plan that makes them work together optimally.

Who should NOT get EBOO?

EBOO is safe and appropriate for the vast majority of people, but a few groups should avoid it. Understanding contraindications helps ensure you’re protected. First, anyone with severe G6PD deficiency (a genetic condition affecting red blood cells) cannot have EBOO. The ozone exposure could trigger hemolysis (red blood cell breakdown). If you know you have G6PD deficiency, inform us immediately. G6PD testing is simple if you’re unsure. Second, pregnant women typically avoid EBOO as a precaution, though research suggests it’s safe. We recommend waiting until after pregnancy and nursing to avoid any theoretical risk. Third, patients with active tuberculosis or certain infections may need to avoid EBOO during acute infection—antibodies are being generated and EBOO might interfere with that process. Discuss with our team if you have active infection. Fourth, people with severe uncontrolled heart arrhythmias or unstable cardiovascular conditions should be evaluated carefully. EBOO activates the immune system and increases circulation—we need to ensure your heart can handle this. Fifth, patients with severe clotting disorders (beyond those managed by blood thinners) may not be good candidates. Our screening process identifies these. Sixth, anyone with an allergy or sensitivity to ozone (extremely rare) cannot have EBOO. Seventh, patients actively undergoing chemotherapy should check with their oncologist first—sometimes EBOO can enhance chemo effects, sometimes it should be spaced out. Beyond these contraindications, EBOO is remarkably safe. We screen all new patients thoroughly to ensure safety. If you have any medical condition you’re uncertain about, mention it at your consultation. Our job is to determine if EBOO is right for you.

Why travel to CPRC for EBOO instead of a local clinic?

This gets to the heart of why patients from across the Southeast choose Charleston Pain Relief Center. If you have a local EBOO clinic available, you might wonder: why travel? Several reasons make CPRC worth the drive. First, experience and reputation. We’ve been offering EBOO for 18+ years—longer than nearly any U.S. clinic. Our team has treated hundreds of patients and refined protocols based on real outcomes. You’re not an experiment. You’re benefiting from nearly two decades of accumulated wisdom. Second, equipment and protocols. We use state-of-the-art German-designed EBOO equipment maintained to the highest standards. Our protocols are based on European standards (the gold standard globally) not American shortcuts. Third, expertise. Our physicians and technicians are specifically trained in regenerative medicine, not just administering basic EBOO. We understand how to combine EBOO with stem cell therapy, PRP, and other protocols. We can personalize treatment based on your specific condition. Fourth, track record. Our 377+ five-star reviews aren’t random—they reflect consistent, exceptional outcomes. Patients travel to CPRC because they’ve heard from others that we deliver results. Fifth, integration. We can coordinate EBOO with other regenerative therapies at CPRC. If you need both EBOO and stem cells, you’re getting a coordinated, synergistic plan—not two unrelated treatments. Sixth, patient experience. We’ve invested in creating a comfortable, professional, welcoming environment. You’re not in a rush. Our staff takes time with you. Finally, if a local clinic offers something called “EBOO” but you’ve never heard of it or found limited information about it online, be cautious. CPRC’s reputation is established and verifiable. We’re a known entity. For serious regenerative medicine, that matters. Bottom line: proximity is convenient, but expertise and results matter more. Many patients who initially seek local options eventually choose CPRC after research. The drive is worth it when it means the difference between marginally effective treatment and transformative healing.