Short answer
EBOO and EBO2 are two names for the same therapy. Both mean extracorporeal blood oxygenation and ozonation: your blood flows out through an IV line in a slow, steady stream, passes through a filter where it meets ozone and oxygen, and flows back in.
“EBOO” is the original name, from researchers in Siena, Italy, who published the first report using the name EBOO in 2000. “EBO2” is a newer spelling some clinics use; the “O2” stands for oxygen. We found no registered trademark or medical standard that defines EBO2 as a separate or upgraded treatment.
What really differs from clinic to clinic is the setup: how much blood is processed, whether light is added, and what comes before and after. At Charleston Pain Relief Center in North Charleston, SC, we will walk you through exactly what our session includes.
The story behind the name
People love asking where EBOO came from, so here is the short version, told in four scenes.
Scene 1 · Siena, Italy
Ozone meets the blood
At the University of Siena, physiologist Velio Bocci spent decades studying how ozone interacts with blood.
Scene 2 · The year 2000
The name “EBOO” is born
A Siena team including Nicola Di Paolo and Velio Bocci published “Extracorporeal blood oxygenation and ozonation (EBOO) in man.” That paper gave the therapy its name.
Scene 3 · Across the Atlantic
Wellness clinics adopt it
Integrative and longevity clinics in the U.S. began offering EBOO, each with its own equipment and add-ons.
Scene 4 · Today
“EBO2” shows up
Some clinics now write it “EBO2,” using the chemical symbol for oxygen. Same idea, newer spelling.
What do the letters stand for?
- E = Extracorporeal, which simply means “outside the body.” The blood is treated in a sealed line next to you, then returned.
- B = Blood.
- O = Oxygenation.
- O = Ozonation, meaning exposure to ozone.
- EBO2 swaps the last two letters for “O2,” the symbol for oxygen. It is still extracorporeal blood oxygenation and ozonation.
EBOO vs EBO2 at a glance
| Question | EBOO | EBO2 |
|---|---|---|
| Full name | Extracorporeal blood oxygenation and ozonation | The same name, written with “O2” for oxygen |
| Where the name comes from | Published research from Siena, Italy (2000) | A later spelling used by some clinics; no single source |
| Core process | Blood out, through a filter with ozone and oxygen, back in | The same |
| Trademark or official standard | None that defines the protocol | None found |
| Blood processed | Varies by clinic and by person | Varies by clinic; some advertise larger amounts |
| Light therapy added | At some clinics, including ours | At some clinics |
So is EBO2 “better” than EBOO?
You will see some clinics describe EBO2 as an upgraded “2.0” version, often pointing to more blood processed, an extra filter, or a light device. Those descriptions come from the clinics offering it. We have not found any independent study or standard showing that a treatment called “EBO2” is different from, or better than, one called “EBOO.”
The better question is not which name a clinic uses, but what its session actually includes. That is what you can compare.
Comparing EBOO clinics: 6 questions to ask
- Who performs the treatment, and what are their credentials?
- About how much blood is processed in a session? Expect a range, because it depends on each person’s flow.
- Is light therapy part of the circuit?
- What happens before and after? Some clinics offer the blood treatment alone; others build a full recovery visit around it.
- Is there a consultation first? A good clinic talks with you before booking.
- What is included in the price? Ask so you are comparing like for like.
Curious if EBOO fits you?
Text us about EBOO
Texts go to (843) 604-2276. Your text is already written. Just press send.
What an EBOO day looks like at Charleston Pain Relief Center
Here is our session, step by step, so you know exactly what to expect. Each step has a job on your EBOO day. Choose any card to see that service.
STEP 1Free wellness call
We learn your goals and answer your questions before anything is booked.
Why it matters for EBOO: We make sure EBOO fits your goals and health history, and we tell you about the quick lab we need first. You walk in knowing exactly what will happen.
See the free wellness call →
STEP 2PEMF first
Your visit starts with a PEMF (pulsed electromagnetic field) session.
Why it matters for EBOO: Gentle magnetic pulses help you relax and settle in, so you start your EBOO calm and comfortable.
See PEMF therapy →
STEP 3EBOO with full-spectrum light
This is the heart of your visit. Our EBOO setup includes a full-spectrum light kit.
Why it matters for EBOO: This is the main event. You relax in a comfy recliner while our team takes care of everything.
See EBOO therapy →
STEP 4NEO red light bed
Next comes a session in our NEO red light bed.
Why it matters for EBOO: It is a warm, relaxing way to rest after EBOO, and many people look forward to it.
See red light therapy →
STEP 5IV therapy
An IV follows right after.
Why it matters for EBOO: It gives you fluids and nutrients after your EBOO, so you are rehydrated before you head home.
See IV therapy →
STEP 6Power Plate
You finish on the Power Plate, then you are on your way.
Why it matters for EBOO: A few minutes of gentle vibration gets you up and moving again after resting, so you leave feeling ready for the drive home.
See Power Plate →
Is EBOO FDA-approved?
No. No device used for EBOO has been approved or cleared by the FDA, and EBOO (by either name) is not FDA-approved to diagnose, treat, cure or prevent any disease. We offer it as a wellness service and are clear about that. If you have a medical condition, keep working with the clinicians who manage it, and tell us about it on your wellness call.
Frequently asked questions
Is EBO2 the same as EBOO?
Yes. Both names describe extracorporeal blood oxygenation and ozonation. EBO2 is a newer spelling that uses “O2,” the symbol for oxygen.
What does EBOO stand for?
Extracorporeal Blood Oxygenation and Ozonation. “Extracorporeal” means outside the body.
Where did EBOO come from?
From researchers in Siena, Italy. A team including Nicola Di Paolo and Velio Bocci published the first report using the name EBOO in 2000.
Who came up with the name EBO2?
We could not find a single source. It appears to be a spelling clinics adopted later, and it is not a trademark or a separate protocol.
Is EBO2 more advanced than EBOO?
Claims that EBO2 is an upgrade come from clinics that offer it. No independent standard defines EBO2 as a different or stronger treatment. Compare what each clinic’s session includes instead.
How much blood is processed in a session?
It varies by clinic and by person. At Charleston Pain Relief Center, our EBOO processes about 2 liters, depending on your flow.
Do you offer EBO2 in Charleston?
Yes, under its original name. Our EBOO is the same therapy other clinics may call EBO2, with a full-spectrum light kit, PEMF before, and red light, IV therapy and Power Plate after.
How is EBOO different from 10-pass ozone or major autohemotherapy?
With 10-pass ozone and major autohemotherapy, a set amount of blood is drawn into a bag or bottle, mixed with ozone, and returned, sometimes in several rounds. EBOO works as a continuous circuit: blood flows out, through the filter and back in, steadily, for the whole session.
How much does EBOO or EBO2 cost?
It varies by clinic and by what the session includes. The easiest way to get a straight answer for your situation is a free wellness call with us.
Where is Charleston Pain Relief Center?
2294 Otranto Rd, North Charleston, SC 29406. More than half of our patients travel to see us.
How do I get started?
Text or call 843-604-2276, or schedule a free wellness call. We will answer your questions first, then help you plan your EBOO day.
Keep reading
- EBOO therapy in North Charleston: the full guide
- What to expect during your first EBOO session
- Is EBOO therapy safe?
- How PEMF fits with EBOO
Sources
- Di Paolo N, Bocci V, Garosi G, et al. Extracorporeal blood oxygenation and ozonation (EBOO) in man. Preliminary report. International Journal of Artificial Organs. 2000;23(2):131–141. PubMed 10741810
- Bocci V, Zanardi I, Travagli V, Di Paolo N. Oxygenation-ozonation of blood during extracorporeal circulation. I. In vitro efficiency of a new gas exchange device. Artificial Organs. 2007;31(9):743–748. University of Siena archive
- U.S. trademark search for “EBO2” (no registrations found, checked October 2026). trademarkia.com
Charleston Pain Relief Center · 2294 Otranto Rd, North Charleston, SC 29406 · 843-604-2276 · Last updated 22 October 2026. This article is educational and is not a substitute for individual medical advice. No device used for EBOO has been approved or cleared by the FDA, and EBOO is not FDA-approved to diagnose, treat, cure or prevent any disease.